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Related Experiment Video

Updated: Jun 20, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Consensus and controversies in platelet transfusion.

Neelam Marwaha¹, R R Sharma

¹Department of Transfusion Medicine, PGIMER, Chandigarh, India. neelam2918@yahoo.com

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis

|September 1, 2009

Summary

This summary is machine-generated.

Platelet transfusion therapy optimizes care for patients with low platelet counts. Current research focuses on evidence-based guidelines, cost-effective strategies, and pathogen inactivation to improve patient outcomes.

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Published on: February 14, 2017

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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Area of Science:

Hematology
Transfusion Medicine
Oncology

Background:

Platelet transfusion is essential for managing thrombocytopenia in hemato-oncological disorders and bone marrow failure.
Intensive chemoradiotherapy often necessitates prophylactic and therapeutic platelet transfusions.
Existing guidelines are evolving towards lower transfusion triggers based on emerging evidence.

Purpose of the Study:

To review current advancements in platelet transfusion therapy.
To identify and discuss challenges in optimizing transfusion strategies.
To address critical issues such as transfusion dose, concentrate choice, and pathogen inactivation.

Main Methods:

Review of current literature and clinical guidelines on platelet transfusion.
Analysis of challenges in balancing efficacy, cost-effectiveness, and patient safety.
Discussion of strategies for managing platelet refractoriness and ensuring product safety.

Main Results:

Development of lower transfusion triggers based on improved evidence.
Ongoing challenges in determining optimal transfusion dose, concentrate type, and interval.
Platelet refractoriness remains a significant clinical challenge requiring matched platelets.
Pathogen inactivation is critical due to the risk of bacterial contamination in platelet concentrates.

Conclusions:

Optimizing platelet transfusion therapy requires balancing scientific evidence with practical, cost-effective implementation.
Addressing platelet refractoriness and ensuring pathogen-free products are key areas for future development.
Continuous research and guideline refinement are necessary to improve outcomes for patients requiring platelet support.