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Updated: Jun 20, 2026

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A method for nanofluidic device prototyping using elastomeric collapse.

Seung-min Park¹, Yun Suk Huh, Harold G Craighead

¹School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA.

Proceedings of the National Academy of Sciences of the United States of America

|September 1, 2009

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A new nanofluidic fabrication method uses controlled microchannel collapse to create complex nanochannels down to 60 nm. This technique enables applications in biomolecular analysis, including DNA elongation and nucleic acid detection.

Area of Science:

Nanotechnology
Biomolecular Engineering
Materials Science

Background:

Nanofluidics offers solutions for biomolecular analysis and optical tuning.
Existing elastomeric nanofluidic fabrication (e.g., polydimethylsiloxane - PDMS) is limited to simple channel geometries.
Current methods struggle with creating complex, high-aspect-ratio nanochannels.

Purpose of the Study:

To introduce a novel nanofluidic fabrication technique.
To enable the creation of complex nanochannel structures with high aspect ratios.
To demonstrate the utility of the fabricated nanochannels for biomolecular applications.

Main Methods:

Controlled collapse of microchannel structures in polydimethylsiloxane (PDMS) molds.
Conversion of the mold's vertical dimension into the nanochannel's lateral dimension.

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Last Updated: Jun 20, 2026

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

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Published on: March 13, 2016

A Microfluidic Technique to Probe Cell Deformability

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

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Fabrication of nanochannels as small as 60 nm.

Main Results:

Successful fabrication of complex nanochannel structures with dimensions down to 60 nm.
Development of design rules for predictable nanochannel formation.
Demonstration of DNA elongation within the fabricated nanochannels.
Application in optofluidic surface-enhanced Raman detection of nucleic acids.

Conclusions:

The controlled microchannel collapse technique provides a versatile method for nanofluidic device fabrication.
This method overcomes limitations of previous techniques, allowing for complex nanochannel geometries.
The demonstrated biomolecular applications highlight the potential of this fabrication approach for diagnostics and analysis.