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Polymorphisms in the VK gene patterns of rheumatoid arthritis patients and control individuals
A Meindl1, H Kellner, M Schattenkirchner
1Institut für Physiologische Chemie, Universität München, BRD.
Experimental and Clinical Immunogenetics
|January 1, 1990
Abstract:
Restriction nuclease digests of DNAs from rheumatoid arthritis patients and control persons were studied by blot hybridization using immunoglobulin VK gene probes of subgroups I-III. Two restriction fragment length polymorphisms (RFLP) were detected in Bg1II digests with a VKI gene probe. One of the RFLPs is linked to rheumatoid arthritis with a relative risk of 5 (p less than 0.01). The observation may be of pathogenetic interest.