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10:28
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Virulence factor activity relationships for hepatitis E and Cryptosporidium
Ronald Fayer1, Palmer Orlandi, Michael L Perdue
1United States Department of Agriculture, Animal and Natural Resources Institute, Environmental Microbial Safety Laboratory, Beltsville, MD 20705, USA. ronald.fayer@ars.usda.gov
Journal of Water and Health
|September 1, 2009
Summary
Hepatitis E virus (HEV) and Cryptosporidium are waterborne pathogens with complex disease factors. Research is ongoing to identify virulence factors for both HEV and Cryptosporidium to understand their pathogenicity.
Area of Science:
- Environmental microbiology
- Infectious diseases
- Parasitology
Background:
- Hepatitis E virus (HEV) and Cryptosporidium are significant waterborne pathogens.
- These pathogens exhibit diverse taxa, genotypes, and isolates, infecting humans and animals.
- The factors contributing to disease development are complex and not fully understood.
Purpose of the Study:
- To explore the complex factors influencing disease caused by HEV and Cryptosporidium.
- To investigate potential virulence factors for HEV and Cryptosporidium.
Main Methods:
- Comparative analysis of pathogen traits (taxon, genotype, isolate).
- Assessment of host-related factors (age, immune status, physiology).
- Review of recent genetic discoveries related to Cryptosporidium virulence.
Main Results:
- Disease association varies among HEV and Cryptosporidium isolates.
- Pathogenicity is influenced by a combination of pathogen traits, infectious dose, and host factors.
- No specific virulence factors have been identified for HEV yet.
Conclusions:
- Understanding HEV and Cryptosporidium pathogenicity requires investigating both pathogen and host factors.
- Further research into Cryptosporidium genes involved in host cell interaction may reveal virulence factors.
- Identifying virulence factors is crucial for developing effective control strategies against these waterborne diseases.
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