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Diffuse large B-cell lymphoma of mandible: a case report
Raghavendra Kini1, Ankit Saha, Vathsala Naik
1Dept. of Oral Medicine and Radiology, A.J. Institute of Dental Sciences, N.H.17, Kuntikana, Mangalore, Karnataka. India-575004. raghkini@yahoo.co.in
Medicina Oral, Patologia Oral Y Cirugia Bucal
|September 1, 2009
Summary
Non-Hodgkin's lymphoma, a cancer of the lymphoreticular system, can rarely affect the jaw. This case highlights successful chemotherapy treatment for a mandibular large B-cell lymphoma, showing complete regression.
Area of Science:
- Oncology
- Hematology
- Oral and Maxillofacial Surgery
Background:
- Non-Hodgkin's lymphomas (NHL) are neoplasms of the lymphoreticular system, with 40% originating from extranodal sites.
- Primary bone involvement by NHL is rare, with jaw lesions more common in the maxilla than the mandible.
- Clinical presentation of jaw lymphomas is often non-specific, mimicking other pathologies.
Observation:
- A rare case of primary non-Hodgkin's lymphoma of the mandible presented as a diffuse swelling.
- The patient, an elderly male, exhibited symptoms mimicking periapical pathology.
- Diagnosis was confirmed via biopsy and immunohistochemistry.
Findings:
- The patient was diagnosed with a large B-cell lymphoma of the mandible.
- No distant metastasis was detected.
- Chemotherapy resulted in complete regression of the mandibular swelling.
Implications:
- This case underscores the importance of considering lymphoma in the differential diagnosis of jaw lesions, especially in elderly males.
- Effective management of primary mandibular lymphoma can be achieved with chemotherapy.
- Complete resolution and sustained remission are achievable with appropriate oncological treatment.