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Related Experiment Video

Updated: Jun 20, 2026

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

Dicer is required for proper liver zonation.

Shigeki Sekine¹, Reiko Ogawa, Michael T Mcmanus

¹Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan. ssekine@ncc.go.jp

The Journal of Pathology

|September 1, 2009

Summary

Dicer is crucial for liver zonation, ensuring proteins are correctly localized. Loss of Dicer disrupts this, causing widespread periportal protein expression, impacting liver metabolic zonation.

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Area of Science:

Hepatology and Molecular Biology
Gene Regulation and RNA Biology

Background:

Liver lobules exhibit metabolic zonation, with region-specific gene and protein expression.
Dicer, an enzyme essential for microRNA biogenesis, is investigated for its role in liver zonation.

Purpose of the Study:

To investigate the role of Dicer in establishing liver metabolic zonation.
To examine the impact of Dicer deficiency on the localization of key liver proteins.

Main Methods:

Hepatocyte-specific Dicer1 knockout mouse model.
Immunohistochemistry to analyze protein distribution in liver lobules.

Main Results:

Pericentral protein localization was largely maintained in Dicer1-deficient livers.
Periportal proteins (e.g., PCK1, E-cadherin, Arg1, CPS1) lost their zonation and were diffusely expressed.
Glutamine synthetase showed expanded pericentral expression.

Conclusions:

Dicer plays a critical role in establishing and maintaining liver zonation.
Dicer is essential for suppressing periportal protein expression, likely indirectly via Wnt/beta-catenin signaling.