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Related Concept Videos

Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

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Related Experiment Video

Updated: Jun 20, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

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Published on: February 16, 2017

Visualizing canonical Wnt signaling during mouse craniofacial development.

Preethi Mani1, Andrew Jarrell, John Myers

  • 1Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|September 1, 2009
PubMed
Summary

Canonical Wnt signaling is crucial for mouse embryonic head and face development. This study maps its activity, revealing sustained expression across tissues, suggesting sequential roles in craniofacial development.

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Related Experiment Videos

Last Updated: Jun 20, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone
10:03

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone

Published on: May 10, 2019

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Wnt signaling is essential for embryonic development, particularly craniofacial morphogenesis.
  • Understanding Wnt signaling's precise roles in different head and face cell lineages is an active research area.

Purpose of the Study:

  • To characterize canonical Wnt signaling activity during mouse embryonic craniofacial development.
  • To map the spatial and temporal expression patterns of Wnt signaling in the developing head and face.

Main Methods:

  • Utilized a TCF/Lef-LacZ transgenic reporter mouse model.
  • Analyzed reporter gene expression in representative sections of embryonic craniofacial development.

Main Results:

  • Demonstrated a pattern of sustained Wnt signaling reporter activity across most craniofacial tissues.
  • Identified dynamic expression patterns suggesting sequential involvement of Wnt signaling.

Conclusions:

  • Canonical Wnt signaling plays a continuous and multifaceted role throughout craniofacial development.
  • The findings provide a detailed atlas of Wnt signaling activity, aiding future research into craniofacial abnormalities.