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Related Experiment Video

Updated: Jun 20, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

[Lessons from the Greek dengue epidemic of 1927-1928].

Claude Chastel¹

¹chastelc@aol.com

Bulletin De L'Academie Nationale De Medecine

|September 2, 2009

Summary

This summary is machine-generated.

Greece experienced a severe dengue outbreak in 1927-1928, causing over a million illnesses and 1500 deaths. This historical event, driven by Aedes aegypti mosquitoes and dengue type 1 virus, highlights Europe

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Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination

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Published on: July 4, 2007

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Last Updated: Jun 20, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination

Published on: July 4, 2007

Area of Science:

Epidemiology and Virology
Vector-borne disease surveillance

Context:

Historical dengue epidemics in Greece, with a notable severe outbreak in 1927-1928.
Identification of Aedes aegypti as the sole vector and dengue type 1 virus as the primary etiological agent.
Comparison with a recent Chikungunya outbreak in Italy, involving Aedes albopictus.

Purpose:

To document the severity and geographic extent of the 1927-1928 Greek dengue outbreak.
To analyze the epidemiological characteristics and etiological agents involved.
To assess the current risk of exotic viral disease emergence in Europe.

Summary:

The 1927-1928 Greek dengue outbreak affected over a million people, causing approximately 1500 deaths, with two epidemic waves.
Severe clinical manifestations, including hemorrhagic, neurological, and renal disorders, were observed during the second wave.
Dengue type 1 virus transmitted by Aedes aegypti was identified; the role of dengue type 2 remains unclear.

Impact:

The historical outbreak provides insights into the potential impact of arboviruses in Europe.
The emergence of invasive Aedes mosquitoes (e.g., Aedes albopictus) increases the risk of future exotic viral disease outbreaks.
Europe faces an ongoing risk from imported viral diseases due to international travel.