Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low intensity vibration with zoledronate reduces musculoskeletal weakness and adiposity in estrogen deprived female mice.

Nature communications·2026

Same author

TGF‑β at the Crossroads: Orchestrating the Bone Metastatic Microenvironment and Shaping Therapeutic Frontiers.

Frontiers in bioscience (Landmark edition)·2026

Same author

Microenvironmental and Molecular Pathways Driving Dormancy Escape in Bone Metastases.

International journal of molecular sciences·2025

Same author

Adipocyte-Tumor Interactions in the Bone Marrow Niche: Implications for Metastasis and Therapy.

International journal of molecular sciences·2025

Same author

Epigenetic Modulation and Bone Metastasis: Evolving Therapeutic Strategies.

Pharmaceuticals (Basel, Switzerland)·2025

Same author

Activating <i>RET</i> Mutations Promotes Osteoblastic Bone Metastases in Medullary Thyroid Cancer.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

Agents targeting prostate cancer bone metastasis.

Khalid S Mohammad¹, Pierrick G Fournier, Theresa A Guise

¹Department of Medicine, Division of Endocrinology, Indiana University, Indianapolis, Indiana 46202, USA.

Anti-Cancer Agents in Medicinal Chemistry

|September 2, 2009

Summary

Advanced prostate cancer frequently spreads to the bone, causing incurable tumors and significant morbidity. Bone-targeted treatments are crucial for managing skeletal metastases and improving survival in prostate cancer patients.

More Related Videos

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Related Experiment Videos

Last Updated: Jun 20, 2026

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Area of Science:

Oncology
Skeletal Biology
Cancer Metastasis

Background:

Bone is the most common site for metastasis in advanced prostate cancer.
Skeletal metastases are currently incurable and lead to significant patient morbidity and mortality.
The bone microenvironment presents unique interactions that can be targeted for therapeutic intervention.

Purpose of the Study:

To highlight the critical role of bone metastasis in prostate cancer progression.
To emphasize the need for improved bone-targeted therapies.
To underscore the importance of preclinical models for evaluating new treatments.

Main Methods:

Review of current understanding of prostate cancer bone metastasis.
Discussion of therapeutic strategies targeting the bone microenvironment.
Emphasis on the necessity of animal models for preclinical evaluation.

Main Results:

Bone metastases from prostate cancer are a major cause of morbidity and mortality.
Standard cancer treatments can exacerbate bone loss, worsening skeletal metastases.
Bone-targeted agents can prevent treatment-induced bone loss and reduce skeletal morbidity.

Conclusions:

Improved bone-targeted treatments are essential for reducing skeletal morbidities in metastatic prostate cancer.
These treatments hold potential for improving overall survival in prostate cancer patients.
Further development and preclinical evaluation in bone metastasis models are required.