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Individualized antianginal therapy guided by systemic arterial pressure

A Schneeweiss1, L Reisin

  • 1Cardiovascular Research Foundation, Geneva, Switzerland.

The American Journal of Cardiology
|June 4, 1990
PubMed

Insights

For patients with angina pectoris, avoid antianginal drugs that also lower blood pressure if they have normal or low blood pressure. Nitrates are a safer initial choice for these individuals.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Antianginal drugs, excluding nitrates, are commonly used as first-line antihypertensive treatments.
  • The impact of pretreatment blood pressure on the antianginal efficacy of these drugs is not well-established.

Purpose of the Study:

  • To evaluate the relationship between pretreatment blood pressure and the effectiveness of antianginal drugs.
  • To determine appropriate initial antianginal therapy for patients with varying blood pressure levels.

Main Methods:

  • Review of existing literature on antianginal and antihypertensive drug classes.
  • Analysis of potential risks associated with excessive blood pressure reduction in angina treatment.

Main Results:

  • Certain antianginal drugs may worsen ischemic conditions by excessively lowering blood pressure.
  • Nitrates demonstrate a favorable profile without significant blood pressure-lowering effects.

Conclusions:

  • In normotensive and hypotensive patients with angina, initiating treatment with drugs that do not primarily reduce blood pressure is recommended.
  • Nitrates represent a suitable option for initial angina management in these patient groups pending further comparative studies.

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