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WikiPharma - a freely available, easily accessible, interactive and comprehensive database for environmental effect
Linda Molander1, Marlene Gerstrand, Christina Rudén
1Royal Institute of Technology/Philosophy, Teknikringen 78B, 10044 Stockholm, Sweden.
Regulatory Toxicology and Pharmacology : RTP
|September 2, 2009
Summary
Active Pharmaceutical Ingredients (APIs) are found in the environment. WikiPharma is a free, continuously updated database compiling ecotoxicity data for APIs to aid environmental risk assessment.
Area of Science:
- Environmental Science
- Ecotoxicology
- Pharmaceutical Science
Background:
- Active Pharmaceutical Ingredients (APIs) are increasingly detected in environmental compartments, including surface waters.
- Existing data on the environmental hazards of APIs are limited, hindering comprehensive risk assessment.
- There is a need for accessible, consolidated information on the ecotoxicity of pharmaceuticals.
Purpose of the Study:
- To create a centralized, publicly accessible database of ecotoxicity data for Active Pharmaceutical Ingredients (APIs).
- To provide a comprehensive and up-to-date overview of the ecological effects of pharmaceuticals on non-target organisms.
- To facilitate the identification of data gaps and support environmental risk assessments for APIs.
Main Methods:
- Compilation of publicly available ecotoxicity data for APIs.
- Development of a wiki-style database (WikiPharma) for continuous updates and free access.
- Extraction of ecotoxicity test data from 156 diverse sources.
Main Results:
- The WikiPharma database currently includes information on 831 APIs across 35 drug classes.
- Ecotoxicity data have been identified and incorporated for 116 APIs.
- The database provides basic information such as substance name, ATC codes, and pharmaceutical groups.
Conclusions:
- The WikiPharma database serves as a valuable resource for understanding the environmental impact of APIs.
- Consolidating ecotoxicity data aids in identifying knowledge gaps and promotes robust environmental risk assessment.
- The free and continuously updated nature of WikiPharma enhances its utility for researchers and regulators.
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