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Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...

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Updated: Jun 20, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Emerging inhaled bronchodilators: an update.

M Cazzola1, M G Matera

  • 1Dipartimento di Medicina Interna, Università di Roma 'Tor Vergata', Italy. mario.cazzola@uniroma2.it

The European Respiratory Journal
|September 2, 2009
PubMed
Summary
This summary is machine-generated.

New long-acting bronchodilators are in development for chronic obstructive pulmonary disease and asthma. Once-daily dosing aims to improve patient adherence and treatment effectiveness.

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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Area of Science:

  • Pharmacology and Respiratory Medicine
  • Drug Development

Background:

  • Bronchodilators are essential for managing chronic obstructive pulmonary disease (COPD) and asthma symptoms.
  • Expired patents have spurred renewed research into novel bronchodilator development.
  • Improving patient adherence through convenient dosing is a key development strategy.

Purpose of the Study:

  • To review emerging long-acting bronchodilator compounds.
  • To discuss the advantages and current status of these new drug candidates.

Main Methods:

  • Review of current research and development in bronchodilator therapy.
  • Analysis of novel beta(2)-agonists and antimuscarinic agents.
  • Evaluation of combination inhaler strategies.

Main Results:

  • Several long-acting bronchodilators, including beta(2)-agonists and antimuscarinic agents, are under development.
  • Once-daily formulations are a primary focus to enhance patient adherence.
  • Combination inhalers targeting multiple pathways are also being explored.

Conclusions:

  • The development of long-acting bronchodilators is driven by medical needs and market opportunities.
  • Once-daily administration represents a significant advancement in COPD and asthma management.
  • Ongoing research promises improved therapeutic options for respiratory conditions.