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Updated: Jun 20, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Published on: February 21, 2018

Interleukin-12 receptor beta2: from cytokine receptor to gatekeeper gene in human B-cell malignancies

Vito Pistoia1, Claudia Cocco, Irma Airoldi

  • 1Laboratory of Oncology, Department of Experimental and Laboratory Medicine, G. Gaslini Institute, 16147 Genova, Italy. vitopistoia@ospedale-gaslini.ge.it

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|September 2, 2009
PubMed

Interleukin (IL) -12 is a cytokine that has been extensively characterized for its immunoregulatory activities. IL-12 binds to a heterodimeric receptor composed of the beta1 and beta2 chains. In this review article, we discuss recent findings on the expression and function of IL-12 receptor (IL-12R) in malignant B cells frozen at various stages of differentiation and in their normal counterparts. These studies, together with others performed in Il12rb2 knockout mice, have established the concept that the IL-12Rbeta2 gene is a gatekeeper from cancer. We will delineate three paradigms reflecting the differential expression of IL-12Rbeta2 in different groups of malignant B cells and discuss the therapeutic perspectives stemming from these studies.

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