Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating stem cell autograft in malignant lymphomas.

I Majolino1, R Scimè, A Indovina

  • 1Divisione di Ematologia, Ospedale V. Cervello, Palermo, Italy.

Haematologica
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Single photon emission computed tomography in focal liver lesions].

Minerva gastroenterologica e dietologica·2006
Same author

The gated equilibrium ventriculography in the diagnosis of the diastolic heart failure.

Minerva cardioangiologica·2005
Same author

Early restaging positron emission tomography with 18F-fluorodeoxyglucose in aggressive non-Hodgkin's lymphomas: is it too easy to be true?

Annals of oncology : official journal of the European Society for Medical Oncology·2003
Same author

Metastatic colorectal cancer: integrating irinotecan into combination and sequential chemotherapy.

Annals of oncology : official journal of the European Society for Medical Oncology·2003
Same author

Minidose warfarin is associated with a high incidence of International Normalized Ratio elevation during chemotherapy with FOLFOX regimen.

Annals of oncology : official journal of the European Society for Medical Oncology·2003
Same author

High rate of remission and low rate of disease recurrence in patients with multiple myeloma allografted with PBSC from their HLA-identical sibling donors.

Bone marrow transplantation·2003

Autologous peripheral blood stem cells (PBSC) transplantation facilitated prompt hematologic recovery in most lymphoma patients. This approach shows promise for disease-free survival post-chemotherapy.

Area of Science:

  • Hematology
  • Oncology
  • Stem Cell Transplantation

Background:

  • Relapsed lymphoma patients often require intensive treatment.
  • Autologous stem cell transplantation is a key consolidation strategy.
  • Peripheral blood stem cells (PBSC) are increasingly used for collection.

Purpose of the Study:

  • To evaluate the efficacy of autologous PBSC for hematologic reconstitution in lymphoma patients.
  • To assess engraftment and clinical outcomes following myeloablative chemotherapy and PBSC infusion.

Main Methods:

  • Three patients with Hodgkin's (n=2) and non-Hodgkin's lymphoma (n=1) in second remission received autologous PBSC.
  • PBSC were collected using a Fenwal CS-3000 cell separator and cryopreserved.
  • A CVB chemotherapy regimen was used as myeloablative conditioning prior to PBSC infusion.

Related Experiment Videos

Main Results:

  • Prompt and complete hematologic recovery was observed in two patients.
  • One patient with Hodgkin's lymphoma experienced delayed thrombocytopenia and granulocytopenia.
  • All patients remained alive and disease-free at 148-301 days post-transplant.

Conclusions:

  • Autologous PBSC transplantation is effective for hematologic reconstitution in lymphoma patients.
  • Most patients achieve prompt engraftment and favorable disease-free survival.
  • Further investigation may be warranted for patients with complex treatment histories.