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Graves' Disease I: Introduction

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Related Experiment Video

Updated: Jun 20, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Benzylthiouracil-induced glomerulonephritis.

Sihem Trimeche Ajmi¹, Rim Braham, Sarra Toumi

¹Department of Endocrinology, Farhat Hached Hospital, 4000 Sousse, Tunisia.

Case Reports in Medicine

|September 2, 2009

Summary

Benzylthiouracil (BTU) can cause rare but severe antineutrophil cytoplasmic antibody (ANCA) vasculitis with glomerulonephritis. Early ANCA testing is crucial for patients experiencing systemic symptoms during BTU therapy.

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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

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Published on: November 10, 2021

Area of Science:

Nephrology
Rheumatology
Endocrinology

Background:

Antithyroid drugs (ATDs) are associated with rare complications like vasculitis.
Propylthiouracil (PTU) was the first ATD linked to vasculitis.
Benzylthiouracile (BTU) is another ATD used for Graves' disease.

Observation:

A 50-year-old man with Graves' disease on BTU developed malaise and hematuria.
He presented with acute kidney injury, proteinuria, and hematuria.
Skin rash and respiratory symptoms were absent.

Findings:

Antineutrophil cytoplasmic antibody (ANCA) testing was positive with antimyeloperoxidase (MPO) specificity.
Renal biopsy confirmed pauci-immune extracapillary glomerulonephritis and vasculitis.
The patient was diagnosed with rapidly progressive glomerulonephritis induced by BTU.

Implications:

Discontinuation of BTU and treatment with steroids and immunosuppressants led to significant renal recovery.
Persistent positive P-ANCA was noted for 10 months post-withdrawal.
This case highlights BTU as a potential cause of severe ANCA-associated vasculitis and glomerulonephritis, emphasizing the need for ANCA monitoring during ATD therapy.