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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

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Related Experiment Videos

Staphylococcus pseudintermedius necrotizing fasciitis in a dog.

J Scott Weese1, Roberta Poma, Fiona James

  • 1Departments of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. jsweese@uoguelph.ca

The Canadian Veterinary Journal = La Revue Veterinaire Canadienne
|September 2, 2009
PubMed
Summary

Staphylococcus pseudintermedius caused a fatal necrotizing fasciitis in a dog. This finding suggests staphylococci, not just Streptococcus canis, should be considered in canine necrotizing fasciitis cases.

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Area of Science:

  • Veterinary Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Necrotizing fasciitis is a severe bacterial infection.
  • Streptococcus canis is the commonly identified pathogen in canine necrotizing fasciitis.
  • Staphylococcus pseudintermedius is a common bacterium in dogs.

Observation:

  • A dog presented with rapidly progressive and fatal necrotizing fasciitis.
  • The causative agent was identified as Staphylococcus pseudintermedius.
  • The isolate was methicillin-susceptible and lacked Panton-Valentine leukocidin genes.

Findings:

  • Staphylococcus pseudintermedius can cause severe necrotizing fasciitis in dogs.
  • This case highlights a less common etiology for this severe infection.
  • The specific virulence factors of this isolate remain to be elucidated.

Implications:

  • Veterinarians should consider Staphylococcus pseudintermedius in the differential diagnosis of canine necrotizing fasciitis.
  • This broadens the spectrum of bacterial pathogens associated with this life-threatening condition in dogs.
  • Further research into staphylococcal virulence factors in necrotizing fasciitis is warranted.