Related Experiment Video
Updated: Jun 20, 2026

In Vitro Polymerization of F-actin on Early Endosomes
Published on: August 28, 2017
The Elmo family forms an ancient group of actin-regulating proteins
Joseph A Brzostowski1, Petra Fey, Jianshe Yan
1Laboratory of Immunogenetics Imaging Facility; National Institutes of Health; Rockville, MD USA.
Abstract:
The Elmo protein family members are important mediators of small G protein activity, regulating actin-mediated processes such as chemotaxis and engulfment. Until recently,1 Elmo function has not been explored in professional phagocytes such as Dictyostelium discoideum. We discuss the significance of this family with respect to pathways that regulate Rac signaling, we present a comparison of Elmo proteins between representative taxa, and discuss our findings on ElmoA, one of six Elmo proteins found in D. discoideum.
Related Concept Videos
Introduction to Actin
Actin Polymerization and Cell Motility
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.
Formation of Higher-order Actin Filaments
The high-order actin networks...
Generation of Straight or Branched Actin Filaments
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
Actin Filament Depolymerization
In F-actin, the ADF/cofilin proteins...
Cytoskeletal Accessory Proteins

