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Updated: Jun 20, 2026

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images
Published on: August 31, 2022
Cell-cell nanotubes: Tunneling through several types of synapses
Alexander O Tarakanov1, Larisa B Goncharova
1St. Petersburg Institute for Informatics and Automation; Russian Academy of Sciences; St. Petersburg, Russia.
Abstract:
Nanotube can be generally seen as a nanoscale cylindrical structure. Membrane (or tunneling) nanotube (TNT) is a cytoplasmic tunnel between two cells. Such direct cell-cell channel is used for a physical transport of biochemical cargo, whereas nanotubular networks between cells may be a novel principle of communicative and integrative biology. Recently, TNTs and their networks were discovered in plant cells and then they were reported also in animal cells. Just the reverse, a notion of plant synapse has been also proposed only recently, long after the corresponding notion of neuronal synapse in animals. However, both TNTs and synapses seem to be closely related and evolutionary conserved structures through different types of cells. Accordingly, this mini-review aims to demonstrate that TNTs may represent one of the deep functional similarities between neuronal, immune, viral and plant synapses.
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