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Updated: Jun 20, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
Conjugated linoleic acid (CLA): effect modulation of body composition and lipid profile
A Baddini Feitoza1, A Fernandes Pereira, N Ferreira da Costa
1Nutrition Institute Josue de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. abaddininutricao@gmail.com
Abstract:
Conjugated linoleic acid (CLA) refers to a family of polyunsaturated fatty acids, being represented by a group of isomers of linoleic acid called conjugated for having a double bound after a simple bound. Among its isomers, trans-10,cis-12 and cis-9, cis-12 CLA stand out. These isomers can lead to different effects on the body: anticarcinogenic, antidiabetogenic, antiatherogenesis and positive body composition alteration. The objective of this review is to describe their mechanisms of action, effects on body composition, on plasmatic lipoproteins and supplementation. Studies about CLA supplementation show its capacity of reducing fat percentage, body mass and of promoting an improvement in lipid metabolism. One of the adverse effects attributed to one of the isomers is insulin resistance by body fat redistribution. Limitations in the scientific models used in CLA researches make impossible to draw conclusions about the action of this fatty acid on human metabolism.
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