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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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International expert consensus recommendations on standardised nomenclature of SSA/Ro (TROVE2/Ro60 and TRIM21/Ro52) autoantibodies in autoimmune diseases.

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Related Experiment Video

Updated: Jun 20, 2026

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

Future perspective for diagnosis in autoimmune diseases.

Luis E C Andrade1

  • 1Divisão de Reumatologia, Universidade Federal de São Paulo, Escola de Medicina, São Paulo, SP, Brasil. luis.andrade@unifesp.br

Anais Da Academia Brasileira De Ciencias
|September 2, 2009
PubMed
Summary

Scientific advancements have improved disease management, but systemic inflammatory diseases like lupus still require novel treatments. Personalized medicine, guided by pharmacogenetics, offers a promising new direction for these complex conditions.

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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

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Last Updated: Jun 20, 2026

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Area of Science:

  • Medicine
  • Genetics
  • Immunology

Background:

  • Disease understanding evolved from mystical concepts to a scientific approach integrating anatomy, microbiology, biochemistry, physiology, immunology, pathology, and pharmacology.
  • Current medical practices and disease classification stem from this integrated knowledge.
  • Despite progress, existing approaches are insufficient for systemic inflammatory conditions like systemic lupus erythematosus, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To explore novel therapeutic approaches for systemic inflammatory and autoimmune diseases.
  • To investigate the potential of applying insights from chronic auto-inflammatory syndromes to systemic autoimmune diseases.
  • To highlight the role of pharmacogenetics in advancing personalized medicine.

Main Methods:

  • Review of scientific literature on disease management evolution.
  • Analysis of breakthroughs in understanding chronic auto-inflammatory syndromes.
  • Exploration of the interaction between environmental stimuli and gene polymorphisms in autoimmune diseases.

Main Results:

  • Molecular dissection of gene defects in auto-inflammatory syndromes has paved the way for targeted therapies.
  • Systemic autoimmune diseases may arise from interactions between environmental factors and multiple gene polymorphisms.
  • Pharmacogenetics principles offer a pathway toward personalized medicine.

Conclusions:

  • Novel approaches are crucial for managing complex systemic inflammatory diseases.
  • Understanding gene-environment interactions is key to unraveling autoimmune disease pathogenesis.
  • Pharmacogenetics holds significant potential for developing personalized treatment strategies in autoimmune disorders.