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Updated: Jun 20, 2026
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Seasonal distribution and evolving forms of multiple sclerosis patients diagnosed from April 2004 to November 2007
Hermes Fundora-Hernández1, Alberto J Dorta-Contreras, Maray Socias-López
1Laboratorio Central de Líquido Cefalorraquídeo, Facultad de Ciencias Médicas Dr. Miguel enríquez, Instituto Superior de Ciencias Médicas de La Habana, Cuba. hermes.fundora@infomed.sld.cu
Background:
Multiple sclerosis (MS) was first reported in Cuba in 1965. The most frequent appearance is observed in the first six months of the year.
Objective:
To determine the seasonal distribution and evolving forms of MS patients diagnosed with the disease between April 2004 and November 2007.
Method:
Twenty-one patients with suspected MS and 42 outbreaks were studied. Patients were classified according to Lublin and Revingold's criteria for clinical forms and according to McDonald.
Results:
Most patients were classified in outbreak and remission and only two patients classified as primary-progressive multiple sclerosis. The higher number of outbreaks occurred in the first two quarters of the year.
Conclusion:
It is recommended to study further weather variables that may be related to the emergence of these outbreaks in our environment.
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