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Simultaneous screening and quantification of several nonopiate narcotic analgesics and phencyclidine in human plasma
P Kintz1, A Tracqui, A J Lugnier
1Institut de Médecine Légale, Strasbourg, France.
Abstract:
This paper describes a procedure for the quantitative determination of alfentanil, dextromoramide, fentanyl, methadone, pentazocine, pethidine, phenoperidine and phencyclidine in human plasma. Some drug metabolites were included in the study. The procedure involves a simple alkaline extraction technique and capillary gas chromatography separation followed by a nitrogen-selective detection. Concentrations as low as 10 micrograms/l can be routinely evaluated, making this method suitable for use in overdose drug screening, therapeutic drug monitoring and pharmacokinetic studies.