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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

[The most common infections of lung allografts]

Anna Korzeniewska1, Tomasz Dyła, Monika Kosacka

  • 1Klinika Pulmonologii i Nowotworów Płuc Akademii Medycznej we Wrocławiu, Wrocław. anna.korzeniewska1@wp.pl

Pneumonologia I Alergologia Polska
|September 2, 2009
PubMed

Insights

Lung transplant recipients face common infections like Pseudomonas aeruginosa, cytomegalovirus, and Aspergillus fumigatus. Prophylactic treatments and specific cystic fibrosis infections influence outcomes and transplant eligibility.

Area of Science:

  • Infectious diseases
  • Transplantation immunology
  • Pulmonary medicine

Context:

  • Allograft infection is a frequent complication following lung transplantation.
  • Pneumonia etiology involves opportunistic and hospital-acquired microorganisms.
  • Common pathogens include Pseudomonas aeruginosa, cytomegalovirus, and Aspergillus fumigatus.

Purpose:

  • To summarize the common infectious complications after lung transplantation.
  • To highlight the role of prophylactic treatment in infection severity and timing.
  • To discuss infections specific to cystic fibrosis impacting peri- and post-operative mortality.

Summary:

  • Lung transplant recipients are susceptible to various infections, primarily pneumonia caused by opportunistic and hospital-acquired pathogens.
  • Pseudomonas aeruginosa, cytomegalovirus, and Aspergillus fumigatus are frequently identified infectious agents.
  • The management and timing of prophylactic treatments significantly influence infection outcomes.
  • Cystic fibrosis-related infections can increase peri- and post-operative mortality risks.
  • Transplant centers exhibit variability in defining contraindications for transplantation based on specific infections.

Impact:

  • Understanding these infections is crucial for optimizing patient management and improving lung transplant outcomes.
  • This knowledge aids in developing targeted prophylactic strategies and risk stratification.
  • It highlights the need for standardized protocols regarding infection screening and management in lung transplant candidates.

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