Protective ability of locally extracted protein A against pathogenic organisms

This study was conducted to find out the ability of Protein A obtained from a local isolate of Staphylococcus aureus to protect rats against infection by pathogenic organisms. A good amount (5000 microg) of Protein A was extracted from a small quantity (approximately 40 g) of Staphylococcus aureus culture using lysostaphin technique. This extract was found to have protective property against pathogenic Escherichia coli and Pseudomonas aeruginosa in rats even at a low concentration of 50 microg. The crude Protein A extract also compared favourably with imported standard Protein A in the study.