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Published on: July 21, 2011
Gold nanoparticles functionalized with gadolinium chelates as high-relaxivity MRI contrast agents
Loïck Moriggi1, Caroline Cannizzo, Eddy Dumas
1Institut des Sciences et Ingénieurie Chimique, Ecole Polytechnique Fédérale de Lausanne, CH 1015 Lausanne, Switzerland.
Abstract:
Water-dispersible gold nanoparticles functionalized with paramagnetic gadolinium have been fully characterized, and the NMRD profiles show very high relaxivities up to 1.5 T. Characterization using TEM images and dynamic light scattering indicate a particle size distribution from 2 to 15 nm. The gold cores of the nanoparticles do not contribute significantly to the overall magnetic moment.
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