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Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Cancer-Critical Genes I: Proto-oncogenes01:33

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer-Critical Genes I: Proto-oncogenes01:33

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The Ras Gene02:38

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Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Updated: Jun 20, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

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Published on: June 27, 2020

eEF1A2 as a putative oncogene.

Mee-Hyun Lee1, Young-Joon Surh

  • 1National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy and Cancer Research Institute, Seoul National University, Seoul, Korea.

Annals of the New York Academy of Sciences
|September 3, 2009
PubMed
Summary

The protein elongation factor eEF1A2 is overexpressed in ovarian tumors, indicating its role in cancer development. This abnormal expression is linked to a poorer prognosis, suggesting eEF1A2 as a potential cancer biomarker.

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Published on: May 1, 2020

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The protein elongation factor eEF1A2 (eukaryotic translation elongation factor 1 alpha 2) has emerged as a significant factor in cancer research.
  • Initial studies by Anand and colleagues revealed its overexpression in approximately 30% of ovarian tumors and established ovarian cancer cell lines.

Purpose of the Study:

  • To review the oncogenic potential of eEF1A2.
  • To highlight the significance of eEF1A2 as a potential diagnostic marker in various cancers.

Main Methods:

  • Literature review of studies investigating eEF1A2 expression and function in cancer.
  • Analysis of reported correlations between eEF1A2 overexpression and patient prognosis.

Main Results:

  • eEF1A2 is found to be overexpressed in a significant subset of ovarian tumors.
  • Abnormal eEF1A2 expression is associated with a poor prognosis in cancer patients.
  • Evidence suggests eEF1A2's role in promoting tumorigenesis.

Conclusions:

  • eEF1A2 exhibits oncogenic potential and plays a role in tumor development.
  • eEF1A2 overexpression serves as a potential prognostic and diagnostic biomarker in multiple cancer types.
  • Further research into eEF1A2's mechanisms in cancer is warranted.