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Strontium ranelate: new data on fracture prevention and mechanisms of action
Jean-Yves Reginster1, Rita Deroisy, Audrey Neuprez
1Bone and Cartilage Metabolism Research Unit, CHU Centre-Ville, Policliniques L. BRULL, 4020 Liege, Belgium. jyreginster@ulg.ac.be
Abstract:
Osteoporosis treatments need to combine an unequivocally demonstrated reduction of fractures, at various skeletal sites, long-term safety, and a user-friendly profile that optimizes therapeutic adherence. Strontium ranelate is the first compound to simultaneously decrease bone resorption and stimulate bone formation. Its anti-fracture efficacy at various skeletal sites has been established for as long as 5 years through studies of the highest methodological standards. Increases in bone mineral density observed after 1 year of treatment are predictive of the long-term fracture efficacy, suggesting for the first time in osteoporosis that bone densitometry can be used as a monitoring tool. Due to a positive risk/benefit ratio, strontium ranelate is now considered as a first-line treatment in the management of osteoporosis.
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