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Published on: February 6, 2021
Keratitis resulting from Thielavia subthermophila Mouchacca
Panagiotis Theoulakis1, David Goldblum, Stefan Zimmerli
1Klinik und Poliklinik für Augenheilkunde, University of Bern, Inselspital, CH-3010 Bern, Switzerland. ptheoulakis@gmail.com
Purpose:
The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp.
Methods:
We conducted a retrospective chart review.
Results:
A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined margins. Cultures of corneal scrapings and biopsy sequence analysis of the ribosomal internal transcribed spacer region isolated Thielavia subthermophila Mouchacca. Clinically, the organism appeared to respond to topical amphotericin B and oral voriconazole. Best-corrected visual acuity at last follow-up visit counted 0.5.
Conclusions:
A rare case of Thielavia sp. keratitis was successfully treated with topical amphotericin B and oral voriconazole. Newly developed molecular diagnostic tools contribute to the recognition of a widening spectrum of emerging fungal pathogens capable of causing serious ocular infections.
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