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Updated: Jun 20, 2026
Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
Herpes simplex virus keratitis: histopathologic neovascularization and corneal allograft failure
Denise D Garcia1, Roni M Shtein, David C Musch
1Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Purpose:
To identify whether histopathologic presence of neovascularization is predictive for allograft failure following penetrating keratoplasty for herpes simplex virus (HSV) keratitis.
Methods:
Retrospective, interventional case series of 62 consecutive patients with HSV keratitis who underwent penetrating keratoplasty at the Kellogg Eye Center between 1990 and 2000. Reviews of the patients' clinical charts and the histopathologic slides of their excised corneal buttons were performed to identify associations between histopathologic neovascularization and clinical outcomes.
Main Outcome Measure:
To determine whether histopathologic presence of neovascularization predicts allograft failure.
Results:
Histopathologic presence of neovascularization was present in 31% of corneal specimens and predicted subsequent allograft failure (P = 0.002) and HSV recurrence (P = 0.05).
Conclusion:
Histopathologic presence of neovascularization is a risk factor for corneal allograft failure and HSV recurrence.
