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Related Concept Videos

Centrosome Duplication02:25

Centrosome Duplication

The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
Centrosome Duplication02:25

Centrosome Duplication

The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or "prometaphase,"...
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
The Mitotic Spindle02:27

The Mitotic Spindle

The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...
The Mitotic Spindle02:27

The Mitotic Spindle

The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...

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Related Experiment Video

Updated: Jun 20, 2026

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
09:39

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

SAD kinase keeps centrosomes lonely.

Daici Chen, Jackie Vogel

    Nature Cell Biology
    |September 3, 2009
    PubMed
    Summary

    Centrosome duplication ensures one set per cell cycle. New research reveals SADB kinase is crucial for controlling centrosome biogenesis and maintaining cell cycle integrity.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Genetics

    Background:

    • Centrosomes are vital microtubule-organizing centers in eukaryotic cells.
    • Accurate centrosome duplication (once per cell cycle) is essential for genomic stability.
    • Dysregulation of centrosome number is linked to various diseases, including cancer.

    Discussion:

    • The study identifies SADB kinase as a novel regulator of centrosome duplication.
    • SADB kinase activity is critical for proper centrosome assembly and function.
    • This finding sheds light on the molecular pathways governing centrosome biogenesis.

    Key Insights:

    • SADB kinase plays a previously unrecognized role in controlling centrosome duplication.
    • Understanding SADB kinase's function offers new avenues for investigating cell cycle control.

    More Related Videos

    Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
    07:14

    Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

    Published on: September 20, 2019

    Studying Mitotic Checkpoint by Illustrating Dynamic Kinetochore Protein Behavior and Chromosome Motion in Living Drosophila Syncytial Embryos
    13:59

    Studying Mitotic Checkpoint by Illustrating Dynamic Kinetochore Protein Behavior and Chromosome Motion in Living Drosophila Syncytial Embryos

    Published on: June 14, 2012

    Related Experiment Videos

    Last Updated: Jun 20, 2026

    Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
    09:39

    Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

    Published on: December 20, 2014

    Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
    07:14

    Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

    Published on: September 20, 2019

    Studying Mitotic Checkpoint by Illustrating Dynamic Kinetochore Protein Behavior and Chromosome Motion in Living Drosophila Syncytial Embryos
    13:59

    Studying Mitotic Checkpoint by Illustrating Dynamic Kinetochore Protein Behavior and Chromosome Motion in Living Drosophila Syncytial Embryos

    Published on: June 14, 2012

  • This discovery advances our knowledge of molecular mechanisms underlying centrosome biogenesis.

    • Outlook:

    • Further research into SADB kinase could reveal therapeutic targets for diseases associated with centrosome abnormalities.
    • Investigating SADB kinase interactions may uncover additional regulatory components of centrosome duplication.
    • This work provides a foundation for exploring the broader implications of SADB kinase in cell division and development.