Related Experiment Video

Updated: Jun 20, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Bone marrow-derived progenitor cells in the early phase of ischemic stroke: relation with stroke severity and

Francesca Cesari1, Patrizia Nencini, Mascia Nesi

  • 1Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy. francesca.cesari@gmail.com

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|September 3, 2009
PubMed

Insights

Circulating progenitor cells (CPCs) are linked to stroke severity and recovery in ischemic stroke patients. Higher CPC levels correlate with better outcomes and less severe strokes, suggesting their potential as a biomarker.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Hematology

Background:

  • Previous studies indicate a negative correlation between circulating progenitor cells (CPCs) and stroke severity/outcomes in ischemic stroke patients.
  • Endothelial progenitor cells (EPCs) are a subset of CPCs, and their role in stroke recovery requires further investigation.

Purpose of the Study:

  • To simultaneously measure CPCs and EPCs in the acute phase of ischemic stroke.
  • To determine the relationship between CPC/EPC levels, stroke severity (NIH Stroke Scale), and discharge outcomes.

Main Methods:

  • Flow cytometry was used to quantify CPCs and EPCs in 67 acute ischemic stroke patients.
  • Measurements were analyzed against baseline NIH Stroke Scale scores, stroke syndromes, and discharge disposition (home vs. rehabilitation unit).

Main Results:

  • Patients with partial anterior circulation syndrome had higher CPC numbers than those with total anterior circulation syndrome.
  • A negative correlation was observed between admission NIH Stroke Scale score and CPC count.
  • Higher CPC numbers were associated with discharge to home compared to rehabilitation, while EPC numbers showed no significant difference.

Conclusions:

  • The number of CPCs in the early phase of ischemic stroke is associated with neurological severity.
  • CPC levels correlate with discharge outcomes, suggesting their potential as a prognostic biomarker in stroke patients.

More Related Videos

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...