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Updated: Jun 20, 2026

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
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Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications

Published on: March 22, 2020

Single fluorescent gold nanoclusters.

C T Yuan1, W C Chou, J Tang

  • 1Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.

Optics Express
|September 3, 2009
PubMed
Summary
This summary is machine-generated.

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Gold nanoclusters (Au NCs) show potential as nontoxic fluorescent labels, exhibiting fluorescence enhancement and single exponential decay. However, improvements in quantum yield and photostability are needed for optimal lifetime-based imaging microscopy applications.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biophysics

Background:

  • Gold nanoclusters (Au NCs) are explored for their unique optical properties.
  • Understanding fluorescence behavior is crucial for developing novel imaging agents.

Purpose of the Study:

  • To investigate the fluorescence properties of Au nanoclusters (NCs) using ensemble and single-molecule measurements.
  • To assess the potential of Au NCs as nontoxic fluorescent labels for lifetime-based imaging microscopy.

Main Methods:

  • Ensemble fluorescence spectroscopy.
  • Single-molecule fluorescence spectroscopy.
  • Time-resolved fluorescence measurements.

Main Results:

  • Photoinduced fluorescence enhancement observed in ensemble Au NCs.

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Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of Gold(III)
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Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of Gold(III)

Published on: August 31, 2018

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Last Updated: Jun 20, 2026

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
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Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications

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A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening

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  • Photobleaching and fluorescence blinking observed at ambient conditions and single-molecule level.
  • Single exponential fluorescence decay with a lifetime of ~7 ns, insensitive to intensity changes.
  • Homogeneous lifetime distribution in Au NCs compared to CdSe quantum dots (QDs).

    • Conclusions:

    • Au NCs demonstrate potential as nontoxic fluorescent labels for lifetime-based imaging microscopy.
    • Low quantum yields and poor photostability are limitations requiring further research and development.