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Updated: Jun 20, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Valproic Acid-induced hyperammonemia in the elderly: a review of the literature
Vikrant Mittal1, Sunanda Muralee, Rajesh R Tampi
1Parkland Health Center, 1103 West Liberty Street, Farmington, MO 63640, USA.
Abstract:
Valproic acid and its derivatives are commonly used to treat many psychiatric conditions in the elderly. Hyperammonemia is a less common but important side effect of these drugs. The elderly patient appears highly vulnerable to this side effect of this group of medications. In this paper, we systematically review the published literature for hyperammonemia induced by valproic acid and its derivatives. We describe the three reported cases and review possible treatment strategies for this condition.
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