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Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

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The Forced Swim Test as a Model of Depressive-like Behavior
05:42

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

Real-World Data on SSRI Antidepressant Side Effects.

Elisa Cascade1, Amir H Kalali, Sidney H Kennedy

  • 1Ms. Cascade is Vice President, Quintiles Inc./iGuard, Falls Church, Virginia.

Psychiatry (Edgmont (Pa. : Township))
|September 3, 2009
PubMed
Summary

Selective serotonin reuptake inhibitor antidepressants are associated with side effects in 38% of patients, commonly impacting sexual function, sleep, and weight. Many patients do not report bothersome side effects to their doctors.

Keywords:
SSRIantidepressantpatient-reported side effectreal-world data

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Patient-Reported Outcomes

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants.
  • Understanding patient-reported side effects is crucial for treatment adherence and management.

Purpose of the Study:

  • To document patient-reported side effects of commonly prescribed SSRIs.
  • To identify the most frequent SSRI-associated adverse events and their perceived severity.
  • To assess patient communication of side effects to healthcare providers.

Main Methods:

  • A cross-sectional survey of approximately 700 patients using SSRIs (citalopram, escitalopram, fluoxetine, paroxetine, sertraline).
  • Tabulation of reported side effects and their perceived bothersomeness.
  • Analysis of the frequency of side effect disclosure to physicians.

Main Results:

  • 38% of surveyed patients reported experiencing at least one side effect from SSRI use.
  • The most common side effects included sexual dysfunction, somnolence, and weight gain.
  • Only 25% of reported side effects were rated as "very" or "extremely bothersome".
  • 40% of patients discussed their side effects with their prescribing physician, irrespective of severity.

Conclusions:

  • SSRI antidepressants are associated with a notable incidence of patient-reported side effects.
  • Sexual functioning, sleep disturbances, and weight changes are primary concerns for patients.
  • A significant gap exists in patient-physician communication regarding SSRI-related adverse events, even when bothersome.