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Updated: Jun 20, 2026
Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
Published on: April 21, 2016
Electric-field-assisted growth of functionalized poly(3,4-ethylenedioxythiophene) nanowires for label-free protein
Hong Xie1, Shyh-Chyang Luo, Hsiao-Hua Yu
1Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore.
Abstract:
The construction of functionalized poly(3,4-ethylenedioxythiophene) (PEDOT) nanowire devices for label-free protein detection is reported. Direct growth/assembly of PEDOT nanowires with carboxylic acid side-chain functional groups (poly(EDOT-COOH)) across the electrode junction is achieved by using an electric-field-assisted method. These functionalized PEDOT nanowire devices show typical depletion-mode p-type field-effect transistor (FET) properties. Upon conjugation with a protein-binding aptamer, the PEDOT nanowire FET devices are used for label-free electronic detection of a target protein of interest. The binding of a positively charged protein causes a substantial decrease in current flow, attributed to the specific interaction between target protein molecules and aptamer-conjugated polymer chains.
