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Updated: Jun 20, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Sentinel lymph node mapping for gastric adenocarcinoma.

Robert D Becher1, Perry Shen, John H Stewart

  • 1Department of General Surgery, Wake Forest University, Winston-Salem, North Carolina 27010, USA.

The American Surgeon
|September 4, 2009
PubMed
Summary

Sentinel lymph node (SLN) mapping for gastric cancer is feasible but not recommended for clinical use. While SLN identification was successful, its low negative predictive value limits its utility in determining lymphadenectomy extent.

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Area of Science:

  • Surgical Oncology
  • Gastroenterology
  • Pathology

Background:

  • The extent of regional lymphadenectomy for gastric adenocarcinoma is debated.
  • Current methods focus on anatomical nodal stations for resection.
  • Sentinel lymph node (SLN) biopsy offers a potential alternative for nodal metastasis assessment.

Purpose of the Study:

  • To evaluate the feasibility and accuracy of SLN mapping and biopsy in gastric carcinoma.
  • To assess the role of SLN biopsy in guiding lymphadenectomy extent.
  • To determine the utility of immunohistochemistry for detecting micrometastatic disease.

Main Methods:

  • Prospective trial involving 27 patients with gastric cancer.
  • SLN identification using isosulfan blue, followed by resection and pathological evaluation.

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  • Procedure continued with radical gastrectomy and celiac node dissection.

    • Main Results:

    • SLNs were successfully identified in all cases.
    • Eighteen patients (67%) had confirmed nodal metastasis.
    • Positive SLNs were found in 83% of cases; false negative rate was 17%.
    • Overall accuracy was 88.9%, but the negative predictive value was 75%.

    Conclusions:

    • SLN mapping and biopsy are feasible for gastric carcinoma.
    • The 75% negative predictive value necessitates caution in its clinical application for lymphadenectomy.
    • Immunohistochemical detection of micrometastases showed no utility in this study.
    • SLN mapping is not currently recommended for clinical use in gastric cancer management.