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Updated: Jun 20, 2026
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Nine-step enantioselective total synthesis of (+)-minfiensine
Spencer B Jones1, Bryon Simmons, David W C MacMillan
1Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, USA.
Abstract:
An enantioselective total synthesis of the Strychnos alkaloid (+)-minfiensine has been accomplished. Prominent features of this synthesis include (i) a new enantioselective organocatalytic Diels-Alder/amine cyclization sequence to build the central tetracyclic pyrroloindoline framework in four steps from commercial materials and (ii) a 6-exo-dig radical cyclization to forge the final piperidinyl ring system. This total synthesis of (+)-minfiensine was completed in nine chemical steps and 21% overall yield.
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