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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Blood Flow01:29

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.

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A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes
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A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

Published on: February 24, 2023

Bone resorption induced by fluid flow.

Lars Johansson1, Ulf Edlund, Anna Fahlgren

  • 1Department of Management and Engineering, Linkoping University, Linkoping, Sweden. lars.johansson@liu.se

Journal of Biomechanical Engineering
|September 4, 2009
PubMed
Summary
This summary is machine-generated.

This study introduces a new bone remodeling model driven by fluid flow, not just stress. Computer simulations support this fluid-driven pathway for bone resorption and osteoclast activity.

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Area of Science:

  • Biomechanics
  • Cell Biology
  • Computational Modeling

Background:

  • Current bone remodeling models primarily rely on mechanical stimuli like stress and strain.
  • An alternative pathway involving fluid flow dynamics at the bone microenvironment is hypothesized.

Purpose of the Study:

  • To develop and validate a computational model for bone resorption driven by fluid flow.
  • To investigate the role of fluid flow parameters in stimulating osteoclast activity and bone remodeling.

Main Methods:

  • Development of a computational model simulating bone resorption influenced by fluid flow.
  • Comparison of simulation results with experimental data to validate the model.

Main Results:

  • The model demonstrates that fluid flow parameters can act as a stimulus for bone resorption.
  • Experimental evidence supports a pathway where fluid flow history influences osteoclast formation and osteolysis.

Conclusions:

  • Fluid flow dynamics represent a significant, previously underestimated, factor in bone remodeling.
  • This fluid-driven model offers a new perspective on bone resorption mechanisms and potential therapeutic targets.