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Assessment of left ventricular systolic asynchrony in patients with clinical hypothyroidism

Sahin Kaplan1, Abdulkadir Kiriş, Cihangir Erem

  • 1Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. skaplan74@hotmail.com

Echocardiography (Mount Kisco, N.Y.)
|September 4, 2009
PubMed

Insights

Overt hypothyroidism significantly increases left ventricular (LV) asynchrony, a condition where heart segments contract out of sync. This study found a higher prevalence of LV asynchrony in hypothyroid patients using tissue synchronization imaging (TSI).

Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Imaging

Background:

  • Hypothyroidism adversely affects cardiovascular function, including impaired cardiac contractility.
  • Left ventricular (LV) asynchrony is characterized by the loss of simultaneous contraction in cardiac segments.
  • Overt hypothyroidism is associated with various cardiovascular complications.

Purpose of the Study:

  • To evaluate the presence and extent of systolic asynchrony in patients diagnosed with overt hypothyroidism.
  • To compare LV asynchrony parameters between patients with overt hypothyroidism and a control group.

Main Methods:

  • The study included 31 patients with overt hypothyroidism and 26 controls.
  • Echocardiography with tissue synchronization imaging (TSI) was performed on all participants.
  • Four TSI-derived parameters quantifying LV asynchrony were measured, including time to regional peak systolic velocity (Ts).

Main Results:

  • Patients with overt hypothyroidism exhibited significantly prolonged TSI parameters indicative of LV asynchrony compared to controls.
  • The prevalence of LV asynchrony was substantially higher in the hypothyroid group (83.9%) versus the control group (26.9%).
  • Specific measures like the standard deviation of Ts and maximal Ts differences were significantly elevated in hypothyroid patients.

Conclusions:

  • Overt hypothyroidism is associated with significant left ventricular asynchrony.
  • Tissue Synchronization Imaging (TSI) effectively detects LV asynchrony in patients with overt hypothyroidism.
  • These findings highlight a crucial cardiovascular consequence of untreated hypothyroidism.
Abstract

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