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Epigenetic programming of diverse glucocorticoid response and inflammatory/immune-mediated disease
Peisong Chen1, Tang Jiang, Juan Ouyang
1Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Abstract:
Glucocorticoid plays a fundamental role in maintaining immune homeostasis. Resistance to glucocorticoids is a potential etiology of inflammatory/immune-mediated disease. Most of the glucocorticoid effects are mediated by glucocorticoid receptor (GR), which has a complicated promoter region with multiple promoters. Studies have found that the methylation pattern of GR promoter is highly individual, which may contribute to the diverse glucocorticoid responds. Early life is a critical time for epigenetic programming of the body in which methylation imprints are established. Here we propose a hypothesis that connects the adverse early life events and the development of inflammatory/immune-mediated disease through an epigenetic mechanism, the methylation of GR gene.
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