Related Experiment Video
Updated: Jun 20, 2026

Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model
Published on: October 18, 2015
Delayed feedback control of bursting synchronization in a scale-free neuronal network
C A S Batista1, S R Lopes, R L Viana
1Departamento de Física, Universidade Federal do Paraná, 81531-990, Curitiba, Paraná, Brazil.
Abstract:
Several neurological diseases (e.g. essential tremor and Parkinson's disease) are related to pathologically enhanced synchronization of bursting neurons. Suppression of these synchronized rhythms has potential implications in electrical deep-brain stimulation research. We consider a simplified model of a neuronal network where the local dynamics presents a bursting timescale, and the connection architecture displays the scale-free property (power-law distribution of connectivity). The networks exhibit collective oscillations in the form of synchronized bursting rhythms, without affecting the fast timescale dynamics. We investigate the suppression of these synchronized oscillations using a feedback control in the form of a time-delayed signal. We located domains of bursting synchronization suppression in terms of perturbation strength and time delay, and present computational evidence that synchronization suppression is easier in scale-free networks than in the more commonly studied global (mean-field) networks.
Related Concept Videos
Neural Circuits
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
The Synapse
Neuronal Communication
Synaptic Signaling
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Synaptic Signaling
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...

