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Severity of acute gastroenteritis in infants infected by G1 or G9 rotaviruses

Camille Aupiais1, Alexis de Rougemont, Cédric Menager

  • 1Department of Pediatrics, Saint-Vincent-de-Paul-Cochin Hospitals, Assistance Publique Hôpitaux de Paris, and University of Paris Descartes, F-75014 Paris, France.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|September 4, 2009
PubMed

Insights

This study found no difference in clinical severity between G1 and G9 rotavirus infections in hospitalized children. Continued surveillance is essential for emerging rotavirus strains causing severe gastroenteritis.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Group A rotaviruses are a primary cause of severe diarrhea in children.
  • Emerging G9 rotaviruses may cause more severe symptoms due to lack of prior immunity.

Purpose of the Study:

  • To compare the clinical severity of G9 rotavirus infections against G1 infections in hospitalized children.

Main Methods:

  • Prospective study of French children (<5 years) hospitalized for gastroenteritis (2004-2007).
  • Rotavirus detection via ELISA and genotyping by RT-PCR.
  • Comparison of hospitalization duration, Vesikari scores, and intravenous rehydration needs.

Main Results:

  • 162 G1 (n=76) and G9 (n=86) rotavirus infections analyzed.
  • Similar hospitalization duration (mean 2.7 days) and Vesikari scores (G1: 12.96, G9: 12.83).
  • Intravenous rehydration rates were comparable (55.3% for G1, 53.5% for G9).

Conclusions:

  • No significant difference in clinical severity between G1 and G9 rotavirus infections was observed.
  • Ongoing surveillance is crucial for emerging rotavirus strains potentially causing severe disease.
  • Emerging strains may challenge the efficacy of current rotavirus vaccines.
Abstract

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