Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
Lateralization01:28

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment.

JAMA·2026
Same author

Influence of an AQP4 haplotype and sleep duration on early Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Hemorrhage Pattern and Amyloid Burden in Cerebral Amyloid Angiopathy.

Journal of the American Heart Association·2026
Same author

Digital maze test reveals cognitive performance patterns associated with amyloid-β and tau.

Neuropsychology·2026
Same author

Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults.

Nature communications·2026
Same author

Extent of Tau and Its Cognitive Implications in Patients With Cerebral Amyloid Angiopathy Without Cognitive Impairment.

Neurology·2026

Related Experiment Video

Updated: Jun 20, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

Does hippocampal FDG-PET asymmetry predict verbal memory dysfunction after left temporal lobectomy?

Beth A Leeman1, Catherine L Leveroni, Keith A Johnson

  • 1Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. bleeman1@bidmc.harvard.edu

Epilepsy & Behavior : E&B
|September 4, 2009
PubMed
Summary

Hippocampal asymmetries in fluorodeoxyglucose (FDG) uptake did not predict verbal memory decline after epilepsy surgery. However, temporal lobe neocortical asymmetries showed potential predictive value for memory outcomes.

More Related Videos

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
09:58

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Published on: November 9, 2018

Related Experiment Videos

Last Updated: Jun 20, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
09:58

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Published on: November 9, 2018

Area of Science:

  • Neuroimaging
  • Epilepsy Research
  • Cognitive Neuroscience

Background:

  • Temporal lobe epilepsy (TLE) often necessitates surgery, carrying risks of cognitive decline, particularly verbal memory (VM) impairment.
  • Preoperative assessment of brain function is crucial for predicting surgical outcomes in TLE patients.
  • Hippocampal function, often affected in TLE, is critical for memory processes.

Purpose of the Study:

  • To investigate if preoperative hippocampal asymmetries in fluorodeoxyglucose (FDG) uptake predict post-temporal lobectomy verbal memory (VM) decline in patients with left TLE.
  • To explore the utility of automated region of interest (ROI) analysis for quantifying these asymmetries.

Main Methods:

  • Utilized preoperative PET scans with FDG uptake to assess hippocampal metabolism in patients with left TLE.
  • Defined a quantitative asymmetry index (AI) using an automated technique for hippocampal ROIs.
  • Correlated hippocampal AI with changes in verbal memory (Logical Memory Percent Retention) from pre- to post-surgery.

Main Results:

  • No statistically significant association was found between hippocampal FDG-PET asymmetry index and postsurgical verbal memory decline.
  • Post hoc analyses indicated that asymmetries in superior and inferior temporal gyri approached statistical significance.
  • Greater left-sided metabolism in these neocortical areas predicted better verbal memory outcomes.

Conclusions:

  • Preoperative hippocampal FDG-PET asymmetries do not reliably predict verbal memory changes after temporal lobectomy for TLE.
  • Neocortical asymmetries, particularly in the temporal gyri, may offer a more promising avenue for predicting memory outcomes.
  • Findings suggest potential functional reorganization or retained function in TLE patients, warranting further investigation of neocortical AIs.