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Updated: Jun 20, 2026

In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane
Published on: November 28, 2019
[Expression of aquaporin-1 in human oligohydramnios placenta and fetal membranes]
Rong-Zeng Hao1, Hui-Shu Liu, Zheng-Fang Xiong
1Department of Obstetrics and Gynecology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, China. haorongzeng@163.com
Objective:
To detect aquaporin-1 mRNA (AQP1) expression in human oligohydramnios placenta and fetal membranes.
Methods:
Placenta and fetal membranes samples were obtained from 5 women with oligohydramnios and 5 with normal amniotic fluid volume. AQP-1 mRNA expression in the tissue samples was detected by semi-quantitative RT-PCR.
Results:
The expression of AQP1 mRNA was significantly lower in oligohydramnios placenta than in normal pregnancy placenta at term (P<0.05), and also significantly lower in oligohydramnios fetal membranes than in normal fetal membranes at term (P<0.05).
Conclusion:
Alterations in AQP1 mRNA expressions in human placenta and fetal membranes may play an important role in the disorder of maternal-fetal fluid exchange and amniotic fluid volume.
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