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Updated: Jun 20, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
Published on: October 25, 2024
BATF: bringing (in) another Th17-regulating factor
Gustavo J Martinez1, Chen Dong
1Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Abstract:
T helper (Th) 17 cells are a recently identified subset of T cells that regulate tissue inflammation, and RORgammat and RORalpha have been shown to be Th17-specific transcription factors that mediate Th17 cell generation. A new study of Batf-deficient mice shows that this AP-1 family transcription factor also regulates Th17 cell differentiation by binding to Th17-associated gene promoters and by maintaining RORalpha and RORgammat expression, shedding new lights on current clinical modulation of Th17 cell function in inflammatory diseases.
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