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Updated: Jun 20, 2026

A BW Reporter System for Studying Receptor-Ligand Interactions
Published on: January 7, 2019
B cell receptor and BAFF receptor signaling regulation of B cell homeostasis
1Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. wnkhan@med.miami.edu
Abstract:
B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and metabolic fitness during selection at transitional stages and survival after maturation rely on cross-talk between BCR and BR3 signaling. Recent findings have also begun to unravel the molecular mechanisms underlying this crosstalk. In this review I also propose a model for regulating the amplitude of BCR signaling by a signal amplification loop downstream of the BCR involving Btk and NF-kappaB that may facilitate BCR-dependent B cell survival as well as its functional coupling to BR3 for the growth and survival of B lymphocytes.
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