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Updated: Jun 20, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
Treatment of comorbid adolescent cannabis use and major depressive disorder
Yifrah Kaminer1, Daniel F Connor, John F Curry
1Alcohol Research Center and the Division of Child and Adolescent Psychiatry at the University of Connecticut Health Center, Farmington, Connecticut, USA. kaminer@psychiatry.uchc.edu
Abstract:
The comorbidity of unipolar depression with substance use disorders (SUD) in adolescents is well established and accounts for 24 to 50 percent in clinical samples. Very little empirical data exist on the treatment of dually diagnosed youth. The objective of this paper is twofold: 1) We will review the literature on SUD and unipolar depression; and 2) we will provide guidelines for a combined pharmacological and psychosocial intervention based on a clinical case example.
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