Related Experiment Video
Updated: Jun 20, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Cronkhite-Canada syndrome: a case report and review of literature
Kevin T Kao1, Jitesh K Patel, Vijayamalini Pampati
1Department of Gastroenterology, Kaiser Permanente Los Angeles Medical Center, 1526 N. Edgemont Street, Los Angeles, CA 90027, USA. kevinkao1999@hotmail.com
Abstract:
Cronkhite-Canada syndrome (CCS) is a rare syndrome first described in 1955. (1) Since then, 400 cases worldwide have been reported in the literature. The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and abdominal pain. (2) The etiology is currently unknown, but an autoimmune process is suspected. The workup is based on history and physical followed by imaging and endoscopy with biopsy to confirm gastrointestinal polyposis. The goal of treatment focuses on symptomatic management of the patient and nutritional support.
Related Concept Videos
Chronic Kidney Disease II: Clinical Manifestations
Acute Coronary Syndrome III: Diagnostic Studies
Case Studies
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Chronic Kidney Disease I: Introduction
Cardiomyopathy III: Hypertrophic Cardiomyopathy