Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A methylome-based score to predict survival after regorafenib in recurrent glioblastoma.

Neuro-oncology advances·2026
Same author

Advancing the adoption of oncology decision support tools in Europe: insights from CAN.HEAL.

Frontiers in digital health·2026
Same author

Targeting Colorectal Cancer Stem Cells Through Inhibition of the Fibroblast Growth Factor Receptor 4 Pathway with a Novel Antibody.

Cancers·2026
Same author

In vitro assays as a tool to personalize treatment in central nervous system tumors: a systematic literature review.

Clinical and experimental medicine·2026
Same author

The italian national genomic strategy: current status, challenges, and future perspectives in clinical practice and public health.

Journal of community genetics·2025
Same author

DUSP8 as a regulator of glioblastoma stem-like cell contribution to tumor vascularization.

Journal of experimental & clinical cancer research : CR·2025
Same journal

Integrative genetic and functional analysis of autosomal dominant hearing loss in 108 multigenerational families.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Preclinical evaluation of cysteine protease-inhibitor aloxistatin (E64d) for heart failure therapy.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Zinc-binding protein metallothionein 3 protects vascular smooth muscle cells from ferroptosis via blocking lysosomal degradation of GPX4.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Clinical utility of cerebrospinal fluid interleukin-10 in central nervous system lymphoma: a molecular neuropathology-informed diagnostic meta-analysis.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Molecular regulation of PGC-1α: from protein-protein interactions and post-translational modifications to pharmacological modulation.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Molecular determinants of thromboinflammatory activation in inflammatory bowel disease.

Journal of molecular medicine (Berlin, Germany)·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

Colon cancer stem cells.

Lucia Ricci-Vitiani1, Eros Fabrizi, Elisabetta Palio

  • 1Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.

Journal of Molecular Medicine (Berlin, Germany)
|September 4, 2009
PubMed
Summary
This summary is machine-generated.

Colorectal cancer (CRC) is a deadly disease, and current treatments may not target cancer stem cells. Understanding these cells is key to developing effective therapies for colon cancer.

More Related Videos

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
08:39

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

Related Experiment Videos

Last Updated: Jun 20, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
08:39

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

Area of Science:

  • Oncology
  • Stem Cell Biology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer death globally.
  • Advanced CRC lacks curative treatment options.
  • The cancer stem cell model proposes that malignancies originate from self-renewing, tumor-initiating cells.

Purpose of the Study:

  • To review stem cell biology in the context of colorectal cancer.
  • To explore the origins of colon adenomas and cancers.
  • To summarize the role and therapeutic potential of colon cancer stem cells.

Main Methods:

  • Literature review of normal intestinal stem cells and crypt biology.
  • Review of evidence on colon cancer stem cells.
  • Analysis of mechanisms driving tumor development and therapy resistance.

Main Results:

  • Cancer stem cells are implicated in tumor initiation, growth, and resistance to therapy in CRC.
  • Understanding normal stem cell function provides insights into colon cancer origins.
  • Colon cancer stem cells represent a promising therapeutic target.

Conclusions:

  • Cancer stem cells are crucial in colorectal cancer pathogenesis and treatment resistance.
  • Further research into colon cancer stem cells may lead to novel therapeutic strategies.
  • Targeting cancer stem cells holds promise for improving outcomes in colorectal cancer treatment.