ES, iPS, MSC, and AFS cells. Stem cells exploitation for Pediatric Surgery: current research and perspective

Related Experiment Video

Updated: Jun 20, 2026

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
06:28

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

Michela Pozzobon1, Marco Ghionzoli, Paolo De Coppi

  • 1Stem Cell Processing Laboratory, Department of Pediatrics, University of Padova, Padova, Italy.

Pediatric Surgery International
|September 4, 2009
PubMed

Insights

Congenital malformations remain a significant health issue in children. Regenerative medicine, using stem cells and tissue engineering, offers new hope for treating these conditions, especially in pediatric surgery.

Area of Science:

  • Regenerative Medicine
  • Pediatric Surgery
  • Biomedical Engineering

Background:

  • Congenital malformations are a leading cause of childhood morbidity and mortality despite medical advancements.
  • Regenerative medicine aims to restore damaged tissues and organs using living cells.
  • This field integrates tissue engineering and stem cell transplantation for therapeutic applications.

Purpose of the Study:

  • To review the latest advancements in stem cell technology.
  • To explore the potential applications of stem cells in regenerative medicine.
  • To focus on the relevance of these applications within the field of pediatric surgery.

Main Methods:

  • Literature review of recent stem cell research.
  • Analysis of tissue engineering techniques.
  • Examination of stem cell transplantation strategies.

Main Results:

  • Stem cell research has rapidly evolved, offering promising therapeutic avenues.
  • Regenerative medicine strategies show potential for organ and tissue repair.
  • Specific applications are emerging for pediatric surgical interventions.

Conclusions:

  • Stem cell advancements are crucial for the progress of regenerative medicine.
  • Regenerative medicine holds significant promise for improving outcomes in pediatric surgery.
  • Further research is needed to translate these advancements into clinical practice for congenital malformations.

More Related Videos

Use of Human Perivascular Stem Cells for Bone Regeneration07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation05:57

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

Published on: December 30, 2021

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...